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R01 DK067536

Funded outputs count: 141
Funder award ID: R01 DK067536
OpenAlex ID: G1238215490
m6A mRNA methylation regulates pancreatic α-cell plasticity
2026 · Dario F. De Jesus, Natalie K. Brown, et al. · Nature Metabolism
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m 6 A mRNA methylation decorates genes involved in fibrinogen synthesis to regulate liver regeneration in mice
2025 · Tomohiko Kimura, Dario F. De Jesus, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2
Regulatory Roles of IGF2R in Insulin Secretion and Adaptive β-Cell Proliferation
2025 · Jun Shirakawa, Dario F. De Jesus, et al. · Diabetes · 6
Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors
2025 · Adam C. Swensen, Paul D. Piehowski, et al. · Diabetologia · 6
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Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism
2025 · Ling Xiao, Dario F. De Jesus, et al. · Nature Communications · 19
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Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression
2024 · Shota Okagawa, Masaji Sakaguchi, et al. · Nature Communications · 21
m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
2024 · Sevim Kahraman, Dario F De Jesus, et al. · The EMBO Journal · 11
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
2024 · Ling Xiao, Dario F. De Jesus, et al. · Cell Metabolism · 30
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
2024 · Dario F. De Jesus, Zijie Zhang, et al. · Nature Cell Biology · 56
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Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia
2023 · Johanna L. St-Louis, Khadija El Jellas, et al. · Journal of Biological Chemistry · 2
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Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells
2023 · Kanako Iwasaki, Benjamin Lalani, et al. · Frontiers in Endocrinology · 19
NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes
2023 · Dario F. De Jesus, Tomohiko Kimura, et al. · Cell chemical biology · 6
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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
2023 · Giorgio Basile, Amedeo Vetere, et al. · Cell Metabolism · 26
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Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD
2023 · Se-Hyung Park, Robert N. Helsley, et al. · Metabolism · 32
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
2023 · Teresa L. Mastracci, Minoti Apte, et al. · Diabetes · 13
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Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice
2022 · Xuanchun Wang, Yanliang Li, et al. · Nature Communications · 16
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ROCK1 regulates insulin secretion from β-cells
2022 · Byung-Jun Sung, Sung-Bin Lim, et al. · Molecular Metabolism · 7
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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance
2022 · Jun Shirakawa, Yu Togashi, et al. · Cell Reports · 27
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases
2022 · Teresa L. Mastracci, Minoti Apte, et al. · Pancreas · 10
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In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
2022 · Lianhe Chu, Michishige Terasaki, et al. · Cell chemical biology · 15
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Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance
2022 · Ercument Dirice, Giorgio Basile, et al. · JCI Insight · 12
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Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER
2022 · Ryota Inoue, Takahiro Tsuno, et al. · iScience · 19
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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b
2022 · Suraj J. Patel, Nan Liu, et al. · Science Translational Medicine · 41
Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones
2022 · Khyati Girdhar, Marion Soto, et al. · Diabetes · 26
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Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
2022 · Sevim Kahraman, Ercument Dirice, et al. · Nature Metabolism · 56
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