The impact of insulin sensitivity on the potential of metformin to delay age-related inflammation
Description: Numerous studies support the premise that inflammation rises in aging. Drugs with anti- inflammatory actions such as metformin may promote healthspan, the length of one's life spent in good health, especially if given prior to onset of age-related declines. We will analyze deidentified samples from an NIA-funded clinical trial to test the possibility that baseline insulin sensitivity impacts the ability of metformin to ameliorate pathogenic inflammation.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2022-08-15
End date: 2027-04-30
Investigator: BARBARA NIKOLAJCZYK
Institution: UNIVERSITY OF KENTUCKY
Funded outputs count: 9
Funder award ID: R01AG079525
OpenAlex ID: G9000920988