Foxos in the Regulation of Muscle Microphagy
Description: Project Narrative: Uncontrolled diabetes in older individuals can decrease muscle size and strength, and is associated with inefficient energy production in the cellular powerhouses (aka mitochondria). Our previous work has shown that insulin controls muscle size by turning off FoxO proteins to control cellular autophagy, or “self- eating”. The goal of this project is to see if FoxOs also control the self- eating of mitochondria, or “mitophagy”, which will help us better understand the connections between diabetes and muscle weakness that may contribute to disability.
Funding type: research
Funder scheme: R03
Start date: 2017-03-05
End date: 2019-02-28
Investigator: BRIAN TIMOTHY O'NEILL
Institution: UNIVERSITY OF IOWA
Funded outputs count: 4
Funder award ID: R03DK112003
OpenAlex ID: G614671321