A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
Description: Public Health Relevance: Alzheimer's disorder is a neurodegenerative disease characterized by progressive cognitive deterioration affecting in excess of 25 million people worldwide, with the total yearly treatment and care costs estimated to be ~$250 billion. In addition to the characteristic dementia seen in Alzheimer's disorder, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, delusions and hallucinations; these neuropsychiatric syndromes affect >80% of patients, impacting greatly upon the manifestation, treatment and prognosis of the disorder. Increasing our understanding about the causes of the disorder is thus of great public health importance, particularly given the aging trajectory of the population. This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2009-09-30
End date: 2013-08-31
Investigator: JONATHAN MILL
Institution: KING'S COLLEGE LONDON
Funded outputs count: 34
Funder award ID: R01AG036039
OpenAlex ID: G1892418745