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Production of aminosugar-containing hetero-oligosaccharides modulating gut microflora that promotes health and longevity

Description: Galacto-N-biose, an aminosugar-containing hetero-disaccharides, is one of the most promising bifidogenic factors, which is specifically assimilated by bifidobacteria. We produced galacto-N-biose from mucin-type O-glycans of cheese whey glycomacropeptide and gastric mucin as substrates by using the combination of various glycosidases from bifidobacteria.
Amount: ¥5,590,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2012-04-01
End date: 2015-03-31
Investigator: Hisashi ASHIDA
Institution: Kinki University
Funded outputs count: 11
Funder award ID: 24580179
OpenAlex ID: G1243638838
Shifting the focus of d-glucosamine from a dietary supplement for knee osteoarthritis to a potential anti-aging drug
2021 · Hideya Shintani, Hisashi Ashida, et al. · Human Nutrition & Metabolism · 10
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Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction
2018 · Tomoya Shintani, Yuhei Kosuge, et al. · Journal of Applied Glycoscience · 31
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α-N-Acetylglucosaminidase from Bifidobacterium bifidum specifically hydrolyzes α-linked N-acetylglucosamine at nonreducing terminus of O-glycan on gastric mucin
2014 · Yoshimi Shimada, Yuka Watanabe, et al. · Applied Microbiology and Biotechnology · 34
Structural analysis of cerebrosides from Aspergillus fungi: the existence of galactosylceramide in A. oryzae
2014 · Yasushi Tani, Yasunori Amaishi, et al. · Biotechnology Letters · 18
β-Glucuronidase from Lactobacillus brevis useful for baicalin hydrolysis belongs to glycoside hydrolase family 30
2013 · Haruko Sakurama, Shigenobu Kishino, et al. · Applied Microbiology and Biotechnology · 55
Lacto-N-biosidase Encoded by a Novel Gene of Bifidobacterium longum Subspecies longum Shows Unique Substrate Specificity and Requires a Designated Chaperone for Its Active Expression
2013 · Haruko Sakurama, Masashi Kiyohara, et al. · Journal of Biological Chemistry · 104
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Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans
2013 · Toshihiko Katoh, Juri Takase, et al. · Glycobiology · 13
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Crystal Structures of a Glycoside Hydrolase Family 20 Lacto-N-biosidase from Bifidobacterium bifidum
2013 · Tasuku Ito, Takane Katayama, et al. · Journal of Biological Chemistry · 58
Bifidobacterial α-galactosidase with unique carbohydrate-binding module specifically acts on blood group B antigen
2012 · Takura Wakinaka, Masashi Kiyohara, et al. · Glycobiology · 41
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α-N-Acetylgalactosaminidase from Infant-associated Bifidobacteria Belonging to Novel Glycoside Hydrolase Family 129 Is Implicated in Alternative Mucin Degradation Pathway
2011 · Masashi Kiyohara, Takashi Nakatomi, et al. · Journal of Biological Chemistry · 97
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Histological Studies on Myeloma Nephrosis in Bomb Survivors.
1965 · M. Kubo, Hiroaki Takagi, et al. · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
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