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Loss of progenitor function accelerates lung aging

Description: Project Narrative Aging is associated with loss of lung structure, declining function, and increased susceptibility to lung disease, together termed senile emphysema. The goal of this proposal is to define mechanisms that result in loss of adult mesenchymal vascular progenitor and innate lymphoid cell function, contributing to accelerated lung aging and increased susceptibility to emphysema in the aged population.
Funding type: research
Funder scheme: R56
Start date: 2021-09-01
End date: 2023-06-14
Investigator: SUSAN M MAJKA
Institution: NATIONAL JEWISH HEALTH
Funded outputs count: 6
Funder award ID: R56AG073317
OpenAlex ID: G7423174053
2025 · Hannah F. Thorndyke, Evan P. Lundberg, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 1
2023 · Emma C. Mason, Swapna Menon, et al. · Journal of Clinical Investigation · 15
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