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Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension

Description: 8. Project Narrative Aided by preliminary data, the current proposal seeks to address the fundamental relationship between gut and oral microbiota and the host in the context of salt-sensitive hypertension. Genetic and epigenetic cause-effect relationships will be examined using an integrated approach of using custom genetically-altered rat strains and metagenomic, metatranscriptomic and metabolomics approaches.
Funding type: research
Funder scheme: R01
Start date: 2018-07-10
End date: 2023-04-30
Investigator: BINA JOE (lead)
Institutions: University of Toledo, UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
Funded outputs count: 63
Funder award ID: R01HL143082
OpenAlex ID: G3724564304
TRPV4 deletion remodels the gut microbiota and increases colonic ammonia levels
2026 · Ramakumar Tummala, Narendra Babu Kondapalli, et al. · Life Sciences
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Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat
2025 · Juthika Mandal, Sachin Aryal, et al. · Hypertension · 10
Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome
2025 · Sachin Aryal, Blair Mell, et al. · American Journal of Physiology-Cell Physiology · 12
Hypertension Increases Susceptibility to Experimental Malaria in Mice
2024 · Mrunmayee R Kandalgaonkar, Beng San Yeoh, et al. · Function · 5
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Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats
2023 · Xue Mei, Blair Mell, et al. · Pharmacological Research · 24
Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function
2023 · Ravindra Gudneppanavar, Emma Elizabeth Sabu Kattuman, et al. · Journal of Cellular and Molecular Medicine · 26
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Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine
2023 · Sachin Aryal, Ishan Manandhar, et al. · Cambridge Prisms Precision Medicine · 7
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Survey and Evaluation of Hypertension Machine Learning Research
2023 · Clea du Toit, Tran Quoc Bao Tran, et al. · Journal of the American Heart Association · 21
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Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites
2023 · Saroj Chakraborty, Anju Lulla, et al. · Journal of Hypertension · 34
Sex hormones, sex chromosomes, and microbiota: identification of Akkermansia muciniphila as an estrogen-responsive bacterium
2023 · Anil Sakamuri, Pritam Bardhan, et al. · Microbiota and Host · 29
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Microbiota-associated mechanisms underlying sexual dimorphism in hypertension
2023 · John Henry Dasinger, Bina Joe, et al. · Microbiota and Host · 6
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Artificial Intelligence in Medicine: Microbiome-Based Machine Learning for Phenotypic Classification
2023 · Xi Cheng, Bina Joe · Methods in molecular biology · 8
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis
2022 · Hong-Bao Li, Meng-Lu Xu, et al. · Circulation Research · 226
Perceptions of US Medical Students on Artificial Intelligence in Medicine: Mixed Methods Survey Study
2022 · David Shalom Liu, Jake Sawyer, et al. · JMIR Medical Education · 107
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Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis
2022 · Piu Saha, Blair Mell, et al. · Hypertension · 22
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Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors
2022 · Tao Yang, Xue Mei, et al. · Hypertension · 59
Gut commensal Coprococcus comes diminishes the blood pressure‐lowering effect of ester angiotensin‐converting enzyme inhibitors
2022 · Tao Yang, Xue Mei, et al. · The FASEB Journal · 1
Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning
2022 · John W. Turner, Xi Cheng, et al. · Physiological Genomics · 20
Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate
2022 · Cameron G. McCarthy, Emily W. Waigi, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 13
Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
2021 · Aline C. Oliveira, Tao Yang, et al. · Pulmonary Circulation · 14
Physiologic, Metabolic, and Toxicologic Profile of 1,3-Butanediol
2021 · Cameron G. McCarthy, Emily W. Waigi, et al. · Journal of Pharmacology and Experimental Therapeutics · 27
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Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator
2021 · Cameron G. McCarthy, Saroj Chakraborty, et al. · JCI Insight · 78
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14-3-3ζ: A suppressor of inflammatory arthritis
2021 · Joshua Kim, Krista Chun, et al. · Proceedings of the National Academy of Sciences · 24
1,3‐Butanediol at 5% v/v best mimics the systemic and urinary concentrations of β‐hydroxybutyrate after a 24 h fast in adult rats
2021 · Gagandeep Singh, Emily Waigi, et al. · The FASEB Journal
Opioids Cause Vascular Dysfunction in a Sex‐Specific Manner
2021 · Soyoung Cheon, Jeremy Tomcho, et al. · The FASEB Journal