Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology
Description: We have analyzed the basal ganglia network mechanisms in cognitive learning. We found the pathway-specific intracellular signaling in aversive learning. Furthermore, we revealed the involvement of the indirect pathways and dopamine D2L receptors in flexibility of reward learning. Next, we examined reward place learning of mutant DISC1 transgenic mice as a mouse model of mental disorders. We have found the impairment in reward place learning of mutant DISC1 transgenic mice with social isolation stress. Reward-related neural activity was disappeared in hippocampal CA1 place cells of mutant DISC1 mice.
Amount: ¥15,600,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2015-04-01
End date: 2019-03-31
Investigator: Takatoshi HIKIDA
Institution: Osaka University(2018)Kyoto University(2015-2017)
Funded outputs count: 16
Funder award ID: 15H04275
OpenAlex ID: G1279129692