The role of autoantibody as pathogenesis of ideopatic nephrotic syndrome in children
Description: Idiopathic nephrotic syndrome (NS) is a chronic disease that causes severe proteinuria. The aim of this study was to elucidate the pathogenesis of pediatric idiopathic NS by focusing on autoantibodies in the blood of pediatric patients with NS.Our results showed that (1) the autoantibodies in patients' serum were different from anti-IL-4 antibodies predicted before the study began, (2) autoantibodies bind to molecules on renal epithelial cells, which play an important role in the mechanism that prevents protein leakage into the urine, and (3) in vivo experiments using kidney-derived cell lines showed that patient plasma activates pathways required for maintenance of the renal epithelial cell cytoskeleton.These findings suggest that IgM-class autoantibodies in patient plasma may be involved in the pathogenesis of NS.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Kazuhiro Takahashi
Institution: Teikyo University
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 31
Funder award ID: 18K07887
OpenAlex ID: G129812805