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Role of Calcineurin Isoforms in Renal Regulation of Blood Pressure

Description: PROJECT NARRATIVE: This R21 Grant will develop innovative cellular and animal models in order to explore new players in renal sodium handling. The outcomes will enhance our knowledge of specific mechanisms of blood pressure regulation and may highlight a novel direction for antihypertension therapies.
Funding type: research
Funder scheme: R21
Start date: 2018-09-20
End date: 2022-08-31
Investigator: CLINTORIA RICHARDS WILLIAMS
Institution: WRIGHT STATE UNIVERSITY
Funded outputs count: 12
Funder award ID: R21DK119879
OpenAlex ID: G8506390133
3 D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN ‐2‐Mediated Changes
2025 · Estevão Scudese, Andrea G. Marshall, et al. · Aging Cell · 29
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Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes
2024 · Bryanna Shao, Mason Killion, et al. · Journal of Cellular Physiology · 7
Strategies for inducing and validating zinc deficiency and zinc repletion
2024 · Tara-Yesomi Wenegieme, Dalia Elased, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 5
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Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis
2023 · Adaku C. Ume, Tara Y. Wenegieme, et al. · American Journal of Physiology-Renal Physiology · 20
Zinc Deficiency: A Potential Hidden Driver of the Detrimental Cycle of Chronic Kidney Disease and Hypertension
2022 · Adaku C. Ume, Tara-Yesomi Wenegieme, et al. · Kidney360 · 24
Tacrolimus induces ligand independent TGFβ receptor signaling to promote renal fibrosis
2022 · Adaku Ume, Tara Yesomi‐Wenegieme, et al. · The FASEB Journal
Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages
2021 · Shangrila Parvin, Clintoria R. Williams, et al. · Inflammation · 29
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Zinc Deficiency Drives Renal NFkB Activation
2021 · Tara‐Yesomi Wenegieme, Aston Waite, et al. · The FASEB Journal · 1
Calcineurin A-α suppression drives nuclear factor-κB-mediated NADPH oxidase-2 upregulation
2021 · Aswathy M. Cheriyan, Adaku C. Ume, et al. · American Journal of Physiology-Renal Physiology · 6
Calcineurin inhibitors: a double-edged sword
2020 · Adaku C. Ume, Tara-Yesomi Wenegieme, et al. · American Journal of Physiology-Renal Physiology · 47
Calcineurin inhibitor (CNI)‐associated skin cancers: New insights on exploring mechanisms by which CNIs downregulate DNA repair machinery
2020 · Adaku C. Ume, Jennifer M. Pugh, et al. · Photodermatology Photoimmunology & Photomedicine · 32
Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension
2018 · Yu-Jia Zhai, Ming-Ming Wu, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 16
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