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锌指蛋白Zscan4在衰老相关分泌表型发生发展中的作用与机制研究

Amount: ¥600,000
Funding type: grant
Funder scheme: 面上项目
Start date: 2016-01-01
End date: 2020-12-31
Investigator: 宇 孙
Institution: 中国科学院上海营养与健康研究所
Funded outputs count: 22
Funder award ID: 31671425
OpenAlex ID: G1321967720
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
2023 · Xuefeng Dou, Qiang Fu, et al. · Nature Metabolism · 188
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Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
2023 · Hanxin Liu, Qixia Xu, et al. · Aging Cell · 132
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An updated landscape of cellular senescence heterogeneity: Mechanisms, technologies and senotherapies
2023 · Yu Sun · Translational Medicine of Aging · 15
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance
2022 · Changxu Wang, Qilai Long, et al. · Oncogene · 34
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Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance
2022 · Xuefeng Dou, Qilai Long, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
2022 · Yu Sun, Qingfeng Li, et al. · Life Medicine · 105
A New Landscape of Human Dental Aging: Causes, Consequences, and Intervention Avenues
2022 · Yajia Xie, Shuang Chen, et al. · Aging and Disease · 19
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The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
2021 · Qixia Xu, Qiang Fu, et al. · Nature Metabolism · 341
Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies
2021 · Hanxin Liu, Huifang Zhao, et al. · Seminars in Cancer Biology · 96
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RETRACTED ARTICLE: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype
2021 · Boyi Zhang, Qilai Long, et al. · Nature Aging · 66
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Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases
2021 · Qixia Xu, Qiang Fu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
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Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
2020 · Shuling Song, Tamara Tchkonia, et al. · Advanced Science · 129
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RETRACTED: Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles
2020 · Liu Han, Qilai Long, et al. · Cancer Research · 91
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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
2020 · Shuling Song, Eric W.-F. Lam, et al. · Trends in Biochemical Sciences · 195
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression
2019 · Qixia Xu, Qilai Long, et al. · Aging Cell · 141
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Extracellular vesicles in the tumor microenvironment: old stories, but new tales
2019 · Liu Han, Eric W.-F. Lam, et al. · Molecular Cancer · 296
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Senescent cells: A new Achilles’ heel to exploit for cancer medicine?
2018 · Boyi Zhang, Eric W.‐F. Lam, et al. · Aging Cell · 23
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Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
2018 · Fei Chen, Qilai Long, et al. · Nature Communications · 122
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Cellular Senescence: The Sought or the Unwanted?
2018 · Yu Sun, Jean-Philippe Coppé, et al. · Trends in Molecular Medicine · 208
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
2018 · Boyi Zhang, Da Fu, et al. · Nature Communications · 157
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Revisiting ovarian cancer microenvironment: a friend or a foe?
2017 · Boyi Zhang, Fei Chen, et al. · Protein & Cell · 48
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Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies
2017 · L. Han, J. Xu, et al. · Medicinal Research Reviews · 46
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