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Mitochondrial Dysfunction in Aging and Disease

Funding type: program
Funder scheme: P01
Start date: 2007-03-01
End date: 2013-02-28
Investigator: JULIE KAY ANDERSEN
Institution: BUCK INSTITUTE FOR RESEARCH ON AGING
Funded outputs count: 78
Funder award ID: P01AG025901
OpenAlex ID: G370239429
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease
2017 · Dmitri Leonoudakis, Anand Rane, et al. · Mediators of Inflammation · 72
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Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha
2016 · Almas Siddiqui, Anand Rane, et al. · Neurobiology of Disease · 35
Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
2015 · Almas Siddiqui, Dipa Bhaumik, et al. · Journal of Neuroscience · 130
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Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells
2015 · Michael C. Velarde, Marco Demaria, et al. · Proceedings of the National Academy of Sciences · 77
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
2015 · Remi-Martin Laberge, Yu Sun, et al. · Nature Cell Biology · 1,160
Lithium prevents parkinsonian behavioral and striatal phenotypes in an aged parkin mutant transgenic mouse model
2014 · Christopher A. Lieu, Colleen M. Dewey, et al. · Brain Research · 39
Cellular senescence and the aging brain
2014 · Shankar J. Chinta, Georgia Woods, et al. · Experimental Gerontology · 281
The role of mitochondrial function and cellular bioenergetics in ageing and disease
2013 · M.D. Brand, A.L. Orr, et al. · British Journal of Dermatology · 293
Late-life rapamycin treatment reverses age-related heart dysfunction
2013 · James M. Flynn, Monique N. O'Leary, et al. · Aging Cell · 311
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SOD2 in mitochondrial dysfunction and neurodegeneration
2013 · James M. Flynn, Simon Melov · Free Radical Biology and Medicine · 390
A Prototypical Small‐Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production
2013 · Stephen J. McQuaker, Casey L. Quinlan, et al. · ChemBioChem · 23
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Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?
2013 · S. J. Chinta, C. A. Lieu, et al. · Journal of Internal Medicine · 165
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Age-Related Behavioral Phenotype of an Astrocytic Monoamine Oxidase-B Transgenic Mouse Model of Parkinson’s Disease
2013 · Christopher A. Lieu, Shankar J. Chinta, et al. · PLoS ONE · 68
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The Determination and Analysis of Site-Specific Rates of Mitochondrial Reactive Oxygen Species Production
2013 · Casey L. Quinlan, Irina V. Perevoschikova, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 100
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates
2013 · Casey L. Quinlan, Irina V. Perevoshchikova, et al. · Redox Biology · 597
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Strontium Substitution for Calcium in Lithogenesis
2012 · Sarah D. Blaschko, Thomas Chi, et al. · The Journal of Urology · 47
No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease
2012 · Sung W. Choi, Akos A. Gerencser, et al. · Journal of Neuroscience · 28
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Microcomposition of Human Urinary Calculi Using Advanced Imaging Techniques
2012 · Sarah D. Blaschko, Joe Miller, et al. · The Journal of Urology · 33
Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)
2012 · Ajit S. Divakaruni, Dickon M. Humphrey, et al. · Journal of Biological Chemistry · 66
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Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters
2012 · Casey L. Quinlan, Jason R. Treberg, et al. · Free Radical Biology and Medicine · 154
Proteogenomics of synaptosomal mitochondrial oxidative stress
2012 · James M. Flynn, Gregg A. Czerwieniec, et al. · Free Radical Biology and Medicine · 17
Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster
2012 · Subhash D. Katewa, Fabio Demontis, et al. · Cell Metabolism · 168
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Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions
2012 · Casey L. Quinlan, Adam L. Orr, et al. · Journal of Biological Chemistry · 670
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Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium‐induced de‐ and hyperpolarization of neuronal mitochondria
2012 · Akos A. Gerencser, Christos Chinopoulos, et al. · The Journal of Physiology · 223
Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells Do Not Require Glycolysis and Are Not Initiated by Fluctuations in Mitochondrial Bioenergetics
2012 · Isabel Goehring, Akos A. Gerencser, et al. · Journal of Biological Chemistry · 42
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