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Genome-wide Search for CVD Gene-Environment Interactions

Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2002-09-30
End date: 2010-05-31
Investigator: ALAN R. SHULDINER
Institution: UNIVERSITY OF MARYLAND BALTIMORE
Funded outputs count: 182
Funder award ID: U01HL072515
OpenAlex ID: G6130309258
Correlates of C-reactive protein and its prognostic value for cardiovascular outcomes across the cardiovascular–kidney–metabolic spectrum and PREVENT™ risk: A Cross-Cohort Collaboration study
2026 · Zhiqi Yao, Zeina A. Dardari, et al. · American Journal of Preventive Cardiology
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Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program
2026 · Ningyuan Wang, Daniel A. DiCorpo, et al. · Diabetes
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Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC)
2025 · Erfan Tasdighi, Zhiqi Yao, et al. · PLoS Medicine · 25
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Exonic Variation and Its Clinical Impact in 7221 Old Order Amish
2025 · Braxton D. Mitchell, Ebuka Onyenobi, et al. · American Journal of Medical Genetics Part A
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Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm
2025 · Zhiqi Yao, Erfan Tasdighi, et al. · Journal of the American College of Cardiology · 29
General Kernel Machine Methods for Multi‐Omics Integration and Genome‐Wide Association Testing With Related Individuals
2025 · Amarise Little, Ni Zhao, et al. · Genetic Epidemiology · 1
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Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
2024 · Jennifer E Huffman, Jayna Nicolas, et al. · Blood · 18
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Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
2024 · Jessica I. Lundin, Ulrike Peters, et al. · Epigenetics · 10
Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative
2024 · Thibord, F., Wheeler, M., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
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Missense variants in SORT1 are associated with LDL-C in an Amish population
2023 · Kelly A. Mitok, Kathryn L. Schueler, et al. · Journal of Lipid Research · 5
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Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study
2023 · Yuxuan Wang, Margaret Sunitha Selvaraj, et al. · The American Journal of Human Genetics · 14
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Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
2023 · Yanhua Chen, Xiaomeng Du, et al. · Nature Genetics · 215
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Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis
2023 · Shreya C Pal, Nahum Méndez-Sánchez · World Journal of Gastroenterology · 91
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Association of parity with body mass index and cardiometabolic risk in high-parous women
2023 · Shisi He, Patrick F. McArdle, et al. · Menopause The Journal of The North American Menopause Society · 9
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Structural variation across 138,134 samples in the TOPMed consortium
2023 · Goo Jun, Adam C English, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 24
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Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
2022 · Marsha M. Wheeler, Adrienne M. Stilp, et al. · Nature Communications · 21
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Whole genome sequence analysis of blood lipid levels in >66,000 individuals
2022 · Margaret Sunitha Selvaraj, Xihao Li, et al. · Nature Communications · 69
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Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes
2022 · Jennifer L. Halford, Valerie N. Morrill, et al. · Nature Communications · 8
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Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome
2022 · Bin Ni, Shanshan Chen, et al. · Molecular Metabolism · 4
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Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
2022 · Daniel DiCorpo, Sheila M. Gaynor, et al. · Communications Biology · 22
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Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
2022 · Tanika N. Kelly, Xiao Sun, et al. · Hypertension · 32
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
2022 · Mathias Gorski, Humaira Rasheed, et al. · Kidney International · 55
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An Amish founder population reveals rare-population genetic determinants of the human lipidome
2022 · May E. Montasser, Stella Aslibekyan, et al. · Communications Biology · 18
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Rare coding variants in RCN3 are associated with blood pressure
2022 · Karen Y. He, Tanika N. Kelly, et al. · BMC Genomics · 9
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Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen
2021 · May E. Montasser, Cristopher V. Van Hout, et al. · Science · 30
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