Award

Transcriptional regulation of skin stem cells and their niche

Description: Project Narrative: Self-renewal of adult stem cells is a fundamental property required for stem cell maintenance and tissue homeostasis. In this project, we will study hair follicle stem cells and their niche and investigate molecular mechanisms that govern the formation of the hair follicle stem cell compartment. Knowledge gained from the proposed study will provide new insights into the maintenance and aging of hair follicle stem cells and help to develop potential applications using hair follicle stem cells for regenerative medicine.

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding type: research

Funder scheme: R01

Start date: 2017-07-28

End date: 2028-03-31

Investigator: RUI YI

Institution: NORTHWESTERN UNIVERSITY

Funded outputs count: 16

Funder award ID: R01AR071435

OpenAlex ID: G9000913684

Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ

2026 · Edward B. Li, Christopher M. Stephens, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the hair follicle

2026 · Edward B. Li, Meredith Klay, et al. · Journal of Clinical Investigation

Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification

2026 · Arpan Das, Yuheng C Fu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence

2025 · Jingjing Wang, Chaoyu Fu, et al. · Science Advances · 19

scHolography: a computational method for single-cell spatial neighborhood reconstruction and analysis

2024 · Yuheng C. Fu, Arpan Das, et al. · Genome biology · 14

MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

2023 · Dongmei Wang, Haimin Li, et al. · Nature Communications · 23

Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging

2023 · Chi Zhang, Dongmei Wang, et al. · Frontiers in Aging · 11

MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

2023 · Jingjing Wang, Yuheng Fu, et al. · Proceedings of the National Academy of Sciences · 15

Reconstruction of 3-dimensional tissue organization at the single-cell resolution

2023 · Yuheng Fu, Arpan Das, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

Escape of hair follicle stem cells causes stem cell exhaustion during aging

2021 · Chi Zhang, Dongmei Wang, et al. · Nature Aging · 84

Inhibition of microRNA turns back the CLOCK of hair follicle aging

2021 · Chi Zhang, Rui Yi · Nature Aging · 3

Is it time to take R(epressive) out of PRC1?

2019 · Dongmei Wang, Rui Yi · Genes & Development · 3

Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin

2018 · Xiying Fan, Dongmei Wang, et al. · Developmental Cell · 72

The Skin(ny) on Regenerating the Largest Organ to Save a Patient’s Life

2018 · Rui Yi · Cell stem cell · 3

Concise Review: Mechanisms of Quiescent Hair Follicle Stem Cell Regulation

2017 · Rui Yi · Stem Cells · 69

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

2016 · Mathilde Latil, Dany Nassar, et al. · Cell stem cell · 200