Combinatorial epigenetic-based prevention of breast cancer
Description: Public Health Relevance Statement: Estrogen receptor-negative breast cancer is too often fatal and there is a strong need to prevent this disease before it becomes recalcitrant to conventional cancer therapy. An important field-driving and novel goal of this application is to develop dietary combinations of green tea polyphenols and sulforaphane-rich broccoli sprouts that can be safely consumed to reduce estrogen receptor-negative breast cancer risk and severity in offspring generations even when consumed by either of their parents before conception of the offspring.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2014-04-01
End date: 2026-12-31
Investigator: TRYGVE O TOLLEFSBOL
Institution: UNIVERSITY OF ALABAMA AT BIRMINGHAM
Funded outputs count: 75
Funder award ID: R01CA178441
OpenAlex ID: G9000904567