Model of Human Disc Regeneration in the spectrum of Degenerative Disc Disease
Description: NARRATIVE Back pain is the second most common cause of doctor visits and intervertebral disc (IVD) herniation is a direct cause of pain. While discectomy procedures are an effective standard of care for herniation, complications including re-herniation and recurrent back pain at the same level are common. The proposed studies optimize and validate acellular and cell-based IVD repair techniques that advance discectomy procedures by including a reparative component that seals annulus fibrosus defects and restores nucleus pulposus swelling. The robust approach optimizes biomaterials and techniques using bovine organ culture models and validates them using pre-clinical human organ culture and sheep in vivo studies.
Funding type: research
Funder scheme: R01
Start date: 2011-07-15
End date: 2022-02-28
Investigator: JAMES C. IATRIDIS
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 106
Funder award ID: R01AR057397
OpenAlex ID: G6191993650