Award

Normal Aging Lung Cell Atlas (NALCA)

Description: PROJECT NARRATIVE The molecules and regulatory processes involved in lung aging are highly complex and we do not have a comprehensive understanding of this process. The overall objective of the Normal Aging Lung Cell Atlas project is to identify cell and microenvironment specific molecular regulatory events that happen during normative lung aging and use them to develop novel biomarkers and therapeutics. We will share those with the scientific community, through a highly interactive and intuitive web interface called AgeDREMM: the aging lung dynamic regulatory multicellular model.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2019-01-01
End date: 2024-12-31
Investigator: NAFTALI KAMINSKI
Institution: YALE UNIVERSITY
Funded outputs count: 84
Funder award ID: U01HL145567
OpenAlex ID: G8009024933
2026 · Claudia Carducci, Naftali Kaminski, et al. · Frontiers in Medicine · 1
2026 · Lena M. Leiber, Leonard Christian, et al. · European Respiratory Journal · 2
2026 · Aurelien Justet, Venerino Poletti, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Maurizio Chioccioli, Shuyu Liu, et al. · Developmental Cell
2026 · Ruben De Man, Zhongyu Cai, et al. · Aging Cell · 6
2026 · Ruben De Man, John E. McDonough, et al. · Nature Communications · 12
2025 · Yumin Zheng, Jonas C. Schupp, et al. · Nature Biomedical Engineering · 34
2025 · Taylor S Adams, Jonas C Schupp, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 13
2025 · Nancy G. Casanova, Jose D. Herazo-Maya, et al. · American Journal of Respiratory Cell and Molecular Biology · 14
2024 · Qi Song, Alex Singh, et al. · PLoS Computational Biology · 4
2024 · Glenda Trujillo, Alicia Regueiro-Ren, et al. · American Journal of Respiratory and Critical Care Medicine · 8
2024 · Amy Y. Zhao, Avraham Unterman, et al. · American Journal of Respiratory and Critical Care Medicine · 50
2024 · Philip Z. Mannes, Taylor S. Adams, et al. · Science Advances · 15
2024 · Avraham Unterman, Amy Y. Zhao, et al. · American Journal of Respiratory and Critical Care Medicine · 97
2024 · Maurizio Chioccioli, Shuyu Liu, et al. · Developmental Cell · 26
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