Award

Mentoring Obesity and Diabetes Research in Louisiana

Description: PUBLIC HEALTH RELEVANCE (provided by applicant): Obesity and diabetes affect a large and growing segment of the population but Louisiana is disproportionately affected because of the higher incidence of metabolic disease in our state. The COBRE at Pennington is devoted to discovering cellular mechanisms of metabolic disease and translating these discoveries into more effective treatments that will lessen the burden of chronic disease and improve the quality of life.

Funder: National Center for Research Resources

Funding type: program

Funder scheme: P20

Start date: 2006-09-04

End date: 2016-07-31

Investigator: THOMAS W GETTYS (lead)

Institutions: Pennington Biomedical Research Center, LSU PENNINGTON BIOMEDICAL RESEARCH CTR

Topic: Health and Medical Research Impacts

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Funded outputs count: 242

Funder award ID: P20RR021945

OpenAlex ID: G6655571764

Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons

2026 · Laura Kaiser, Nathan Lee, et al. · Communications Biology · 2

Artemisia dracunculus L. Ethanolic Extract and an Isolated Component, DMC2, Ameliorate Inflammatory Signaling in Pancreatic β-Cells via Inhibition of p38 MAPK

2022 · Peter Smoak, Susan J. Burke, et al. · Biomolecules · 9

The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance

2020 · Susan J. Burke, Jessica L. Taylor, et al. · Biomedicines · 4

Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis

2020 · J. Jason Collier, Heidi M. Batdorf, et al. · Molecular Metabolism · 16

Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte‐Specific Oncostatin Receptor Knockout Mice

2018 · Jacqueline M. Stephens, Jennifer L. Bailey, et al. · Obesity · 19

Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels

2018 · Susan J. Burke, Heidi M. Batdorf, et al. · Obesity · 29

A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome

2018 · Asha Jaja-Chimedza, Li Zhang, et al. · Journal of Functional Foods · 87

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue

2018 · Ji Suk Chang, Sujoy Ghosh, et al. · Scientific Reports · 36

A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes

2018 · Ji Suk Chang, Kyoungsoo Ha · PLoS ONE · 19

Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling

2018 · Claudia Kruger, Susan J. Burke, et al. · Redox Biology · 30

The Components of Age‐Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats

2018 · Desiree Wanders, Laura A. Forney, et al. · Obesity · 58

Testing Effects of Chronic Chemogenetic Neuronal Stimulation on Energy Balance by Indirect Calorimetry

2018 · Sangho Yu, Heike Munzberg · BIO-PROTOCOL · 4

Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response

2017 · Laura A. Forney, Kirsten P. Stone, et al. · Frontiers in Neuroendocrinology · 28

High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats

2017 · J M Poret, F Souza-Smith, et al. · International Journal of Obesity · 116

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

2017 · Sheila R. Costford, Bram Brouwers, et al. · Molecular Metabolism · 50

Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding

2017 · Jeffrey D. Covington, Darcy L. Johannsen, et al. · Obesity · 37

The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction

2017 · Laura A. Forney, Kirsten P. Stone, et al. · Applied Physiology, Nutrition, and Metabolism · 10

Genetics-based manipulation of adipose tissue sympathetic innervation

2017 · Marie François, Emily Qualls-Creekmore, et al. · Physiology & Behavior · 14

Harnessing Gut Microbes for Mental Health: Getting From Here to There

2017 · Annadora J. Bruce-Keller, J. Michael Salbaum, et al. · Biological Psychiatry · 193

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

2017 · Cristal M. Hill, Thomas Laeger, et al. · Scientific Reports · 101

The Hypothalamic Preoptic Area and Body Weight Control

2017 · Sangho Yu, Marie François, et al. · Neuroendocrinology · 48

An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice

2017 · Sujoy Ghosh, Laura A. Forney, et al. · PLoS ONE · 45

An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes

2017 · Ji Suk Chang, Kyoungsoo Ha · Journal of Biological Chemistry · 20

Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice

2017 · Ashley P Pettit, William O Jonsson, et al. · Journal of Nutrition · 53

Pancreatic islet inflammation: an emerging role for chemokines

2017 · J Jason Collier, Tim E Sparer, et al. · Journal of Molecular Endocrinology · 68