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Mir-29 mimicry as a therapy for pulmonary fibrosis

Description: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology with an average life expectancy of 3-5 years from initial diagnosis, and 40,000 patients die each year from IPF. The microRNA mir-29, a small non-coding RNAs that regulates the expression of many fibrosis related molecules, is decreased in expression in patients with IPF. The objective of this proposal is to develop microRNA replacement (mimicry) as a viable and novel therapy for this devastating disease and an objective that will have significant impact on the morbidity and mortality of many patients with IPF.
Funding type: cooperative_agreement
Funder scheme: UH2
Start date: 2014-09-22
End date: 2016-08-18
Investigator: NAFTALI KAMINSKI
Institution: YALE UNIVERSITY
Field: Medicine
Funded outputs count: 34
Funder award ID: UH2HL123886
OpenAlex ID: G7456959975
Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows
2026 · Claudia Carducci, Naftali Kaminski, et al. · Frontiers in Medicine · 1
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Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosis
2026 · Aurelien Justet, Venerino Poletti, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
2026 · Jannik Ruwisch, Aurélie Cazes, et al. · Science Advances · 5
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
2026 · Ruben De Man, John E. McDonough, et al. · Nature Communications · 12
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Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort
2025 · Vickram Tejwani, Russell P Bowler, et al. · BMJ Open Respiratory Research · 1
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Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1
2024 · Philip Z. Mannes, Taylor S. Adams, et al. · Science Advances · 15
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SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis
2023 · Ilianna Barbayianni, Paraskevi Kanellopoulou, et al. · Nature Communications · 26
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When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders
2023 · Jonas C. Schupp, Naftali Kaminski · American Journal of Respiratory and Critical Care Medicine · 1
Adult Interstitial Lung Abnormalities: The New Frontier of Pulmonary Fibrosis
2023 · FengMing Luo, Min Zhu, et al. · American Journal of Respiratory and Critical Care Medicine · 5
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1 -Positive Endothelial Cells
2023 · Jonas C. Schupp, Edward P. Manning, et al. · American Journal of Respiratory and Critical Care Medicine · 17
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A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases
2023 · Wei Liu, Wenxuan Deng, et al. · PLoS Genetics · 4
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Rational engineering of lung alveolar epithelium
2023 · Katherine L. Leiby, Yifan Yuan, et al. · npj Regenerative Medicine · 27
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A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs
2023 · Ruben De Man, John E McDonough, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 12
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Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function
2023 · Bianca M. Vamesu, Teodora Nicola, et al. · JCI Insight · 12
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Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases
2022 · Ming Chen, Yiliang Zhang, et al. · Thorax · 9
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Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study
2022 · Richard J Allen, Justin M Oldham, et al. · The Lancet Respiratory Medicine · 68
From COVID to fibrosis: lessons from single-cell analyses of the human lung
2022 · Aurelien Justet, Amy Y. Zhao, et al. · Human Genomics · 21
CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging
2022 · Huachun Cui, Na Xie, et al. · American Journal of Respiratory and Critical Care Medicine · 70
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact
2022 · Laurens J. De Sadeleer, Stijn E. Verleden, et al. · CHEST Journal · 19
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis
2021 · Laurens J. De Sadeleer, John E. McDonough, et al. · American Journal of Respiratory and Critical Care Medicine · 40
A Markov random field model for network-based differential expression analysis of single-cell RNA-seq data
2021 · Hongyu Li, Biqing Zhu, et al. · BMC Bioinformatics · 14
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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
2021 · Linh T. Bui, Nichelle I. Winters, et al. · Nature Communications · 45
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High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF
2021 · Harinath Bahudhanapati, Jiangning Tan, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets
2021 · Michaela T. Reichmann, Liku B. Tezera, et al. · Journal of Clinical Investigation · 40
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Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19
2021 · Kenneth B Hoehn, Palaniappan Ramanathan, et al. · The Journal of Immunology · 40
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