Mitochondrial defects in the retinal pigment epithelium and the CFH risk allele for age-related macular degeneration
Description: Project Narrative The impending health epidemic of age-related macular degeneration (AMD) creates an urgent need to develop treatments that prevent AMD or stop its progression. Because the pathogenesis of AMD is multifactorial, ways need to be developed to make informed decisions about the most efficacious intervention for individual patients or patient subgroups. The studies in this application will test the hypothesis that mitochondrial dysfunction is a key step in AMD pathology for individuals harboring the AMD high risk SNP (rs1061170; amino acid change Y402H) for complement factor H (CFH), the most prevalent AMD patient population and the one with the greatest risk for developing advanced disease.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2018-04-01
End date: 2026-06-30
Investigator: JAMES R. DUTTON
Institution: DOHENY EYE INSTITUTE
Funded outputs count: 22
Funder award ID: R01EY028554
OpenAlex ID: G9000898313