Defining the impact of injection drug use on antiretroviral therapy and HIV treatment outcomes: an (epi)genomic approach
Description: People who inject drug use infected with HIV have high medical comorbidity and poor health outcomes despite the availability of combination anti-retroviral therapy. Our integrative pharmacogenomic approach aims to define a set of genes associated with HIV-infected injection drug use and anti-retroviral therapy that predict HIV outcomes. Our work will generate not only knowledge about how injection drug use perturbs the HIV- infected host epigenome and transcriptome, but also potential biomarkers to predict individual HIV outcomes in the context of combination antiretroviral therapy.
Funder: National Institute on Drug Abuse
Funding type: research
Funder scheme: R01
Start date: 2018-09-30
End date: 2025-07-31
Investigator: BRADLEY E AOUIZERAT
Institution: YALE UNIVERSITY
Funded outputs count: 38
Funder award ID: R01DA047063
OpenAlex ID: G3557287259