Inflammasome Activation in Geographic Atrophy
Description: PUBLIC HEALTH RELEVANCE: There is no FDA-approved treatment for the one million Americans with geographic atrophy (GA) or for the millions more who are at risk of developing GA. We recently discovered an enzymatic deficiency that leads to accumulation of toxic RNA molecules and immune activation in the eyes of patients with GA. By understanding how these newly discovered pathways cause GA and testing therapies that will be suitable for advancing to clinical trials, this proposal is aligned with the National Vision Research Agenda's Needs, Gaps, and Opportunities for the NEI's Retinal Diseases Program strategic plan, and embraces the NIH Director's recent challenge to advance translational science using creative approaches.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2014-09-01
End date: 2018-08-31
Investigator: JAYAKRISHNA AMBATI
Institution: UNIVERSITY OF VIRGINIA
Funded outputs count: 23
Funder award ID: R01EY024068
OpenAlex ID: G6562699636