The Role of Cellular Senescence in Mediating Age-Related Bone Loss
Description: PUBLIC HEALTH RELEVANCE STATEMENT An overwhelming majority of individuals over age 65 suffer from at least two chronic degenerative diseases, including osteoporosis, an enormous public health problem as each year there are approximately 2 million osteoporosis-related fractures with a net cost to the US health care system of $17 billion. Thus, there is a compelling need for novel interventions to prevent and/or treat age-related disorders as a group, rather than treating each condition individually. These studies will provide a better understanding of the molecular events underlying elimination of senescence cells in enhancing healthspan, with a focus on the prevention of skeletal aging. PROJECT NARRATIVE The goal of this project is to better understand the mechanisms underlying elimination of senescence cells in enhancing healthspan, with a focus on the prevention of skeletal aging. These studies will determine the extent to which systemic elimination of senescent cells through genetic and pharmacological approaches prevents age-related bone loss, and whether local elimination of senescent osteocytes is sufficient to prevent skeletal aging.
Funding type: career_development
Funder scheme: K01
Start date: 2016-08-01
End date: 2021-07-31
Investigator: JOSHUA NICHOLAS FARR
Institution: MAYO CLINIC ROCHESTER
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 31
Funder award ID: K01AR070241
OpenAlex ID: G7145008822