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Neurobiological pathways linking stress and emotion to atherosclerosis

Description: The human brain systems linking individual differences in stress and emotion regulation processes to risk for coronary heart disease (CHD) are uncertain. From a public health perspective, it is important to specify these brain systems to (1) understand the mechanistic pathways by which stress and emotion regulation increase or protect against CHD risk and (2) identify markers of stress- and emotion-related neural activity that could be objectively identified and possibly targeted for modification in otherwise healthy people at risk for future CHD.
Funding type: research
Funder scheme: R01
Start date: 2008-04-01
End date: 2019-02-28
Investigator: PETER J GIANAROS
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Field: Medicine
Funded outputs count: 68
Funder award ID: R01HL089850
OpenAlex ID: G79078494
At the intersection of place and race: Neighborhood and racialized exposures associated with brain age gap in midlife
2026 · Amanda L. Johnston, Yemi Tchala, et al. · Brain and Environment
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Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.
2026 · E. Lydia Wu-Chung, Peter J. Gianaros, et al. · Health Psychology
Circulating Antioxidant Nutrients and Brain Age in Midlife Adults
2025 · Mason J. Lower, Mia K. DeCataldo, et al. · Psychosomatic Medicine · 2
Stressor‐Evoked Brain Activity, Cardiovascular Reactivity, and Subclinical Atherosclerosis in Midlife Adults
2025 · Javier Rasero, Timothy D. Verstynen, et al. · Journal of the American Heart Association · 14
Resting-State Functional Connectivity Does Not Predict Individual Differences in Perceived Psychological Stress Among Midlife Adults: Evidence From a Preregistered Cross-Validation Study
2025 · Chrystal Spencer, Javier Rasero, et al. · Psychosomatic Medicine · 3
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
2024 · Ke Bo, Thomas E. Kraynak, et al. · Nature Neuroscience · 70
Subjective Social Status and Longitudinal Changes in Systemic Inflammation
2023 · Emily J Jones, Anna L Marsland, et al. · Annals of Behavioral Medicine · 17
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Beyond Neighborhood Disadvantage: Local Resources, Green Space, Pollution, and Crime as Residential Community Correlates of Cardiovascular Risk and Brain Morphology in Midlife Adults
2023 · Peter J. Gianaros, Portia L. Miller, et al. · Psychosomatic Medicine · 25
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Do trait‐level emotion regulation strategies moderate associations between retrospective reports of childhood trauma and prospective changes in systemic inflammation?
2022 · Emily J. Jones, Anna L. Marsland, et al. · Stress and Health · 20
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Multivariate Brain Activity while Viewing and Reappraising Affective Scenes Does Not Predict the Multiyear Progression of Preclinical Atherosclerosis in Otherwise Healthy Midlife Adults
2022 · Peter J. Gianaros, Javier Rasero, et al. · Affective Science · 12
Integrating multiple brain imaging modalities does not boost prediction of subclinical atherosclerosis in midlife adults
2022 · Amy Isabella Sentis, Javier Rasero, et al. · NeuroImage Clinical · 4
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Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis
2020 · Julian Koenig, Birgit Abler, et al. · Psychophysiology · 53
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Frontostriatal Brain Activation Is Associated With the Longitudinal Progression of Cardiometabolic Risk
2020 · Ben Allen, John Richard Jennings, et al. · Psychosomatic Medicine · 2
Resting Cerebral Blood Flow and Ethnic Differences in Heart Rate Variability: Links to Self-Reports of Affect and Affect Regulation
2019 · Julian F. Thayer, Julian Koenig · NeuroImage · 15
Retrospectively reported childhood physical abuse, systemic inflammation, and resting corticolimbic connectivity in midlife adults
2019 · Thomas E. Kraynak, Anna L. Marsland, et al. · Brain Behavior and Immunity · 52
Ventromedial prefrontal cortex connectivity during and after psychological stress in women
2019 · Annie T. Ginty, Thomas E. Kraynak, et al. · Psychophysiology · 31
The prospective relationship between prehypertension, race, and whole-brain white matter microstructure
2019 · Ben Allen, Matthew F. Muldoon, et al. · Journal of Human Hypertension · 1
Host in the machine: A neurobiological perspective on psychological stress and cardiovascular disease.
2018 · Peter J. Gianaros, J. Richard Jennings · American Psychologist · 86
Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
2018 · Eco J. C. de Geus, Peter J. Gianaros, et al. · Psychophysiology · 219
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Neural Mechanisms Linking Emotion with Cardiovascular Disease
2018 · Thomas E. Kraynak, Anna L. Marsland, et al. · Current Cardiology Reports · 69
Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies
2018 · Thomas E. Kraynak, Anna L. Marsland, et al. · Neuroscience & Biobehavioral Reviews · 165
Higher dietary inflammation is associated with increased odds of depression independent of Framingham Risk Score in the National Health and Nutrition Examination Survey
2018 · Dana Jorgensen, Gretchen E. White, et al. · Nutrition Research · 53
Socioeconomic Position and Age-Related Disparities in Regional Cerebral Blood Flow Within the Prefrontal Cortex
2018 · Daniel A. Hackman, Dora C-H. Kuan, et al. · Psychosomatic Medicine · 8
Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex
2017 · Philip A. Kragel, Michiko Kano, et al. · Nature Neuroscience · 272
A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity
2017 · Peter J. Gianaros, Lei K. Sheu, et al. · Journal of the American Heart Association · 79
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