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Aging of Mesenchymal Stem Cells Missing Link in IPF

Description: PUBLIC HEALTH RELEVANCE: Because the incidence of different types of pulmonary diseases increases with age, independent of exposure to common environmental risk factors. Recently, we have documented functional differences in bone marrow derived mesenchymal stem cells (B-MSCs) between young and old animals, B-MSCs exhibit functional impairments that are not well explained. This observation leads us into our hypothesis that B-MSCs exhibit age-related senescence and decreased effectiveness to participate in the process of lung repair.
Funding type: research
Funder scheme: R01
Start date: 2015-09-01
End date: 2020-06-30
Investigator: MAURICIO ROJAS
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Subfield: Genetics
Field: Medicine
Funded outputs count: 62
Funder award ID: R01HL123766
OpenAlex ID: G8975144258
The Sound of Silence: Suppressing CBX5 Decreases Fibrosis by Inhibiting Fibroblasts
2025 · Mauricio Rojas, Ana L. Mora · American Journal of Respiratory Cell and Molecular Biology
Cardiac matrix-bound Nanovesicles provide insight into mechanisms of clinical heart disease progression to failure
2024 · Madeline Cramer, Matt Borrelli, et al. · International Journal of Cardiology · 7
Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model
2024 · Emily R. Sekera, Lorena Rosas, et al. · Journal of the American Society for Mass Spectrometry · 13
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End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity
2023 · Tamara Cruz, Paula A Agudelo Garcia, et al. · The Journal of Immunology · 22
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Peripheral Immune Cell Profiling Reveals Distinct Immune Hallmarks in Progressive Pulmonary Fibrosis
2023 · Fernanda Hernandez-Gonzalez, Nuria Mendoza, et al. · Archivos de Bronconeumología · 1
An integrated cell atlas of the lung in health and disease
2023 · Lisa Sikkema, Ciro Ramírez-Suástegui, et al. · Nature Medicine · 874
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Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis–Associated Interstitial Lung Disease
2022 · Anna Papazoglou, Mengqi Huang, et al. · Arthritis & Rheumatology · 70
Reduced Proportion and Activity of Natural Killer Cells in the Lung of Patients with Idiopathic Pulmonary Fibrosis
2021 · Tamara Cruz, Minxue Jia, et al. · American Journal of Respiratory and Critical Care Medicine · 36
Human ex vivo lung perfusion: a novel model to study human lung diseases
2021 · Nayra Cárdenes, John Sembrat, et al. · Scientific Reports · 32
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Human Lung-Resident Macrophages Colocalize with and Provide Costimulation to PD1hi Tissue-Resident Memory T Cells
2020 · Mark E. Snyder, John Sembrat, et al. · American Journal of Respiratory and Critical Care Medicine · 39
Topographic heterogeneity of lung microbiota in end-stage idiopathic pulmonary fibrosis: the Microbiome in Lung Explants-2 (MiLEs-2) study
2020 · Eleanor B Valenzi, Haopu Yang, et al. · Thorax · 24
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Lost in Translation: Endoplasmic Reticulum–Mitochondria Crosstalk in Idiopathic Pulmonary Fibrosis
2020 · Marta Bueno, Mauricio Rojas · American Journal of Respiratory Cell and Molecular Biology · 5
Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures
2020 · Haruhiko Furusawa, Jonathan H. Cardwell, et al. · American Journal of Respiratory and Critical Care Medicine · 136
Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma
2020 · Marta Bueno, Anna Papazoglou, et al. · Current Rheumatology Reports · 36
Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis
2020 · Marta Bueno, Jazmin Calyeca, et al. · Redox Biology · 279
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Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery
2020 · Hani N. Alsafadi, Franziska E. Uhl, et al. · American Journal of Respiratory Cell and Molecular Biology · 145
Senescence, the Janus of Lung Injury and Repair
2020 · Shulamit B. Wallach-Dayan, Mauricio Rojas · American Journal of Respiratory Cell and Molecular Biology · 8
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis
2019 · Yingze Zhang, Mao Jiang, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 109
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Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
2019 · Eleanor Valenzi, Melissa Bulik, et al. · Annals of the Rheumatic Diseases · 352
Mesenchymal stem cells reduce ER stress via PERK‐Nrf2 pathway in an aged mouse model
2019 · Eun Joo Lee, Nayra Cárdenes, et al. · Respirology · 30
Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
2019 · Christina Morse, Tracy Tabib, et al. · European Respiratory Journal · 840
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PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses
2019 · Marta Bueno, Daniel Zank, et al. · PLoS ONE · 105
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Cellular Senescence: The Trojan Horse in Chronic Lung Diseases
2019 · Shruthi Hamsanathan, Jonathan K. Alder, et al. · American Journal of Respiratory Cell and Molecular Biology · 87
MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis
2019 · Harinath Bahudhanapati, Jiangning Tan, et al. · Journal of Biological Chemistry · 43
RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia
2019 · Hannah Voic, Xiuying Li, et al. · BMC Genomics · 11
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