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miRNAs in embryonic stem cells during retinal differentiation

Description: PUBLIC HEALTH RELEVANCE: Loss of retinal neurons is the leading cause of vision impairment and blindness, and cellular therapy to replace these lost cells is an attractive approach to restore vision. Embryonic stem cells can be differentiated into retinal neurons and offer a promising unlimited source of new cells for transplantation. In this proposal, we attempt to improve the generation of retinal neurons from mouse and human embryonic stem cell lines.
Funding type: fellowship
Funder scheme: F32
Start date: 2015-09-01
End date: 2018-08-31
Investigator: AKINA HOSHINO
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 5
Funder award ID: F32EY025117
OpenAlex ID: G4384927896
Synchrony and asynchrony between an epigenetic clock and developmental timing
2019 · Akina Hoshino, Steve Horvath, et al. · Scientific Reports · 55
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Development of ON and OFF cholinergic amacrine cells in the human fetal retina
2018 · Chi Zhang, Wan‐Qing Yu, et al. · The Journal of Comparative Neurology · 27
Molecular Anatomy of the Developing Human Retina
2017 · Akina Hoshino, Rinki Ratnapriya, et al. · Developmental Cell · 255
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Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate
2017 · Jennifer R. Chao, Deepak A. Lamba, et al. · Translational Vision Science & Technology · 5
Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human PrimateChao et al.
2017 · Chao, Jennifer R, Lamba, Deepak A, et al. · eScholarship (California Digital Library) · 90
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