Pathophysiology of Biliary Disease
Description: PROJECT NARRATIVE / LAY SUMMARY This project explores how the cholangiocyte epigenome and downstream signaling pathways influence the progression of Primary Sclerosing Cholangitis, a serious liver disease with no effective therapy except liver transplant. We explore the molecular mechanisms that determine if cholangiocytes arrest in the cell cycle (become senescent) or proliferate (resist senescence), and how these two cholangiocyte populations influence the development of fibrosis. If successful, the results could lead to new and effective treatments.
Funding type: research
Funder scheme: R01
Start date: 2000-04-01
End date: 2027-06-30
Investigator: NICHOLAS F. LARUSSO
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 84
Funder award ID: R01DK057993
OpenAlex ID: G9000881867