Mitochondrial regulation of stress reactivity in humans
Description: NARRATIVE There are large unexplained inter-individual differences in systemic allostatic load and stress reactivity, which may in part be explained by mitochondria. Here we study the effects of chronic dysregulation of mitochondrial function – mitochondrial allostatic load (MAL) – on multisystem stress regulation in humans. This project will establish the influence of MAL on baseline AL as well as multisystem stress reactivity profiles, defining novel psychobiological pathways by which mitochondria may contribute to the maintenance of health and resilience, and to disease risk.
Funding type: research
Funder scheme: R01
Start date: 2020-04-15
End date: 2026-03-31
Investigator: MARTIN PICARD
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 46
Funder award ID: R01MH122706
OpenAlex ID: G6601339543