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The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) Network

Description: PUBLIC HEALTH RELEVANCE: In this planning grant we will conduct pilot studies to help design a human study that tests whether epigenetic changes underlie aging as a risk factor for chronic diseases and degenerative conditions.
Funding type: cooperative_agreement
Funder scheme: U34
Start date: 2015-09-30
End date: 2019-05-31
Investigator: STEVE HORVATH
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 47
Funder award ID: U34AG051425
OpenAlex ID: G7159388667
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
2024 · Oshima, J, Horvath, S, et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
Analysis of epigenetic aging in vivo and in vitro : Factors controlling the speed and direction
2020 · Mieko Matsuyama, Arne Søraas, et al. · Experimental Biology and Medicine · 10
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GWAS of epigenetic aging rates in blood reveals a critical role for TERT
2020 · Joehanes, Roby, Bell, Jordana T., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
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DNA methylation aging clocks: challenges and recommendations
2019 · Christopher G. Bell, Robert Lowe, et al. · Genome biology · 1,025
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The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells
2019 · Lisa M. McEwen, Kieran J. O’Donnell, et al. · Proceedings of the National Academy of Sciences · 277
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Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
2019 · Steve Horvath, Ake T. Lu, et al. · Aging · 52
Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT
2019 · Mieko Matsuyama, David J. WuWong, et al. · Aging · 23
Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells
2019 · Arne Søraas, Mieko Matsuyama, et al. · Aging Cell · 44
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Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression
2018 · Sylwia Kabacik, Steve Horvath, et al. · Aging · 68
Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array
2018 · Lisa M McEwen, Meaghan J Jones, et al. · Clinical Epigenetics · 161
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Increased epigenetic age in normal breast tissue from luminal breast cancer patients
2018 · Erin W. Hofstatter, Steve Horvath, et al. · Clinical Epigenetics · 64
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Breast cancer treatment and its effects on aging
2018 · Leslie Chang, Lauren S. Weiner, et al. · Journal of Geriatric Oncology · 82
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
2018 · Steve Horvath, Junko Oshima, et al. · Aging · 815
Genetic and epigenetic changes in clonal descendants of irradiated human fibroblasts
2018 · Julia Flunkert, Anna Maierhofer, et al. · Experimental Cell Research · 29
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Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents
2018 · Steve Horvath, Dan J. Stein, et al. · AIDS · 84
An epigenetic biomarker of aging for lifespan and healthspan
2018 · Morgan E. Levine, Ake T. Lu, et al. · Aging · 3,677
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
2018 · Steve Horvath, Kenneth Raj · Nature Reviews Genetics · 3,091
Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data
2018 · Riccardo E Marioni, Matthew Suderman, et al. · The Journals of Gerontology Series A · 130
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GWAS of epigenetic aging rates in blood reveals a critical role for TERT
2018 · Ake T. Lu, Luting Xue, et al. · Nature Communications · 205
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Leukocyte telomere length, T cell composition and DNA methylation age
2017 · Brian H. Chen, Cara L. Carty, et al. · Aging · 55
Parkinson’s disease is associated with DNA methylation levels in human blood and saliva
2017 · Yu-Hsuan Chuang, Kimberly C. Paul, et al. · Genome Medicine · 168
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GWAS of epigenetic ageing rates in blood reveals a critical role for TERT
2017 · Ake T. Lu, Luting Xue, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Dynamics of epigenetic age following hematopoietic stem cell transplantation
2017 · Friedrich Stölzel, Mario Brosch, et al. · Haematologica · 42
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Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
2017 · Ake T. Lu, Eilis Hannon, et al. · Nature Communications · 123
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Accelerated epigenetic aging in Werner syndrome
2017 · Anna Maierhofer, Julia Flunkert, et al. · Aging · 150
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