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Role of Proximal Tubule NHE3 in Angiotensin II-induced Hypertension

Description: PROJECT NARRATIVE Impaired pressure natriuresis response contributes to poorly controlled hypertension in aging men and postmenopausal women. This project will identify the Na+/H+ exchanger 3 (NHE3) in the proximal tubules of the kidney as a key factor for impaired pressure natriuresis response and therefore a therapeutic target in poorly controlled hypertension. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page
Funding type: research
Funder scheme: R01
Start date: 2014-09-12
End date: 2023-05-31
Investigator: JIA LONG ZHUO
Institution: TULANE UNIVERSITY OF LOUISIANA
Funded outputs count: 45
Funder award ID: R01DK102429
OpenAlex ID: G7180358330
A key role of AT1a receptors and Na+/H+ exchanger 3 in the proximal tubules in angiotensin II-induced and two-kidney, one-clip Goldblatt hypertension
2025 · Xiao Chun Li, Rumana Hassan, et al. · American Journal of Physiology-Renal Physiology
Deletion of AT 1a receptors selectively in the proximal tubules of the kidney alters the hypotensive and natriuretic response to atrial natriuretic peptide via NPR A /cGMP/NO signaling
2024 · Xiao Chun Li, Chih-Hong Wang, et al. · American Journal of Physiology-Renal Physiology · 3
Prenatal diagnosis and treatment for fetal angiotensin converting enzyme deficiency
2023 · Hang‐Jing Tan, Wen‐Yan Jian, et al. · Prenatal Diagnosis · 2
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Recent Advances in Understanding the Molecular Pathophysiology of Angiotensin II Receptors: Lessons From Cell-Selective Receptor Deletion in Mice
2023 · Satoru Eguchi, Matthew A. Sparks, et al. · Canadian Journal of Cardiology · 10
Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases
2023 · Sarah M. Nwia, Ana Paula O. Leite, et al. · Frontiers in Cardiovascular Medicine · 59
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Intracellular Angiotensin II Stimulation of Sodium Transporter Expression in Proximal Tubule Cells via AT1 (AT1a) Receptor-Mediated, MAP Kinases ERK1/2- and NF-кB-Dependent Signaling Pathways
2023 · Xiaochun Li, Jialong Zhuo · Cells · 6
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Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune–Endocrine Organ with Increased MYCN-AP1 Signaling
2023 · Fatma Saaoud, Laisel Martinez, et al. · Cells · 11
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The Renin-Angiotensin-Aldosterone System in Metabolic Diseases and Other Pathologies
2023 · Rudy M. Ortiz, Ryousuke Satou, et al. · International Journal of Molecular Sciences · 3
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Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages
2023 · Charles Drummer, Fatma Saaoud, et al. · Frontiers in Immunology · 76
Genetic Deletion of AT1a Receptor or Na+/H+ Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice
2022 · Xiao Chun Li, Rumana Hassan, et al. · International Journal of Molecular Sciences · 9
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Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting
2022 · Hui Lin, Frank Geurts, et al. · Pharmacological Reviews · 54
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Genetic Evidence for A Critical Role of Intratubular Angiotensin II AT 1a Receptors in The Proximal Tubules of The Kidney in Two‐Kidney, One‐Clip Goldblatt Hypertension in PT‐ Agtr1a ‐/‐ Mice
2022 · Xiao C. Li, Rumana Hassan, et al. · The FASEB Journal
The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension
2022 · Sarah M. Nwia, Xiao Chun Li, et al. · Frontiers in Physiology · 41
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Angiotensin II and AT1a Receptors in the Proximal Tubules of the Kidney: New Roles in Blood Pressure Control and Hypertension
2022 · Ana Paula de Oliveira Leite, Xiao C. Li, et al. · International Journal of Molecular Sciences · 15
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Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury
2021 · Xiao Chun Li, Chih-Hong Wang, et al. · Frontiers in Physiology · 18
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Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney
2021 · Ana Paula Oliveira Leite, Xiao C. Li, et al. · Clinical Science · 16
New Insights into the Critical Importance of Intratubular Na+/H+ Exchanger 3 and Its Potential Therapeutic Implications in Hypertension
2021 · Jia Long Zhuo, Manoocher Soleimani, et al. · Current Hypertension Reports · 12
The Role of Superoxide in Sex Differences in Angiotensin II‐induced Hypertensive and Natriuretic Responses in Mice with Proximal Tubule‐Specific Deletion of Mitochondrial Protein Sirtuin 3 in The Kidney
2021 · Ana Paula Leite, Xiao Li, et al. · The FASEB Journal
Genetic Ablation of The Ren1c and Leptin Genes Improves Insulin and Leptin Sensitivity in Mice
2021 · Chih‐Hong Wang, Xiao Li, et al. · The FASEB Journal
Genetic Deletion of AT 1a Receptors Selectively in The Proximal Tubules of The Kidney Attenuates Angiotensin II‐induced Hypertensive and Glomerular Filtration Responses in Aging PT‐ Agtr1a ‐/‐ Mice
2021 · Xiao Li, Rumana Hassan, et al. · The FASEB Journal
Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT- Agtr1a −/− Mice
2021 · Xiao Chun Li, Ana Paula Oliveira Leite, et al. · Hypertension · 37
Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas
2020 · Xiaohan Tang, Irina Kusmartseva, et al. · American Journal Of Pathology · 33
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Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules
2020 · Xiao Chun Li, Xinchun Zhou, et al. · Hypertension · 22
The Intratubular and Intracrine Renin-Angiotensin System in the Proximal Tubules of the Kidney and Its Roles in Angiotensin II-Induced Hypertension
2019 · Xiao C. Li, Ana Paula de Oliveira Leite, et al. · IntechOpen eBooks
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Proximal Tubule-Specific Deletion of the NHE3 (Na + /H + Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice
2019 · Xiao C. Li, Dongmin Zhu, et al. · Hypertension · 63
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