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The regulation of STING pathway

Description: Stimulator of interferon genes (STING) is essential for the type I interferon response against DNA pathogens. In this project, we examined the regulation of STING pathway, and found that the translocation of STING to lysosome was required for termination of the type I interferon signaling.
Amount: ¥4,290,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Mukai Kojiro
Institution: Tohoku University(2018-2019)The University of Tokyo(2017)
Subfield: Immunology
Funded outputs count: 11
Funder award ID: 17K15445
OpenAlex ID: G1464720695
PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation
2023 · Chiaki Inoue, Kojiro Mukai, et al. · Scientific Reports · 8
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STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
2023 · Yoshihiko Kuchitsu, Kojiro Mukai, et al. · Nature Cell Biology · 219
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Homeostatic regulation of STING by retrograde membrane traffic to the ER
2021 · Kojiro Mukai, Emari Ogawa, et al. · Nature Communications · 165
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A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome
2020 · Zimu Deng, Zhenlu Chong, et al. · The Journal of Experimental Medicine · 205
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FAM48A mediates compensatory autophagy induced by proteasome impairment
2019 · Yoshiyuki Arata, Ayaka Watanabe, et al. · Genes to Cells · 2
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Innate immunity signalling and membrane trafficking
2019 · Tomohiko Taguchi, Kojiro Mukai · Current Opinion in Cell Biology · 129
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STING palmitoylation as a therapeutic target
2019 · Anne Louise Hansen, Kojiro Mukai, et al. · Cellular and Molecular Immunology · 97
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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
2018 · Anne Louise Hansen, Gregory J. Buchan, et al. · Proceedings of the National Academy of Sciences · 301
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The binding of TBK1 to STING requires exocytic membrane traffic from the ER
2018 · Emari Ogawa, Kojiro Mukai, et al. · Biochemical and Biophysical Research Communications · 97
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells
2017 · Tatsuyuki Matsudaira, Kojiro Mukai, et al. · Nature Communications · 55
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El juicio de ponderación en la prisión provincial
1998 · Eduardo de Urbano Castrillo · La Ley: Revista jurídica española de doctrina, jurisprudencia y bibliografía
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