SPIROMICS II: Biological underpinnings of COPD heterogeneity and progression
Description: PROJECT NARRATIVE COPD is heterogeneous and the factors that contribute to disease progression and exacerbations are poorly understood. This study will investigate whether a newly described clinical condition (“Smokers with symptoms despite preserved spirometry”) progresses to COPD. This study will also investigate the mucus abnormalities, inflammatory pathways, and infectious processes that contribute to disease progression and exacerbations in heterogeneous patients with bona fide COPD. The ultimate goal will be to guide the development of therapeutics that target selected individuals with COPD based on their underlying biology.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2017-09-15
End date: 2024-11-30
Investigator: PRESCOTT G WOODRUFF
Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 202
Funder award ID: U01HL137880
OpenAlex ID: G7281172143