Get started
Award

Functions of thioredoxin reductases and their targets

Funding type: research
Funder scheme: R37
Start date: 2002-05-01
End date: 2022-11-30
Investigator: VADIM N. GLADYSHEV
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Funded outputs count: 98
Funder award ID: R37GM065204
OpenAlex ID: G7077592617
Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis
2022 · Qianhui Dou, Anton A. Turanov, et al. · Journal of Biological Chemistry · 39
PDF
Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice
2022 · Huafeng Wang, Qianhui Dou, et al. · Journal of Biological Chemistry · 24
PDF
Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly
2021 · Petra A. Tsuji, Didac Santesmasses, et al. · International Journal of Molecular Sciences · 54
PDF
Reprogramming to recover youthful epigenetic information and restore vision
2020 · Yuancheng Lu, Benedikt Brommer, et al. · Nature · 820
COVID‐19 is an emergent disease of aging
2020 · Didac Santesmasses, José Pedro Castro, et al. · Aging Cell · 172
PDF
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
2020 · Klitos Konstantinidis, Vassilios J. Bezzerides, et al. · Journal of Clinical Investigation · 36
PDF
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity
2020 · Xuming Zhou, Qianhui Dou, et al. · Cell Reports · 34
High‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective role of vitamin E
2020 · Perinur Bozaykut, Ruchan Ekren, et al. · BioFactors · 14
How can aging be reversed? Exploring rejuvenation from a damage‐based perspective
2020 · Bohan Zhang, Vadim N. Gladyshev · Advanced Genetics · 16
PDF
Molecular signatures of aneuploidy-driven adaptive evolution
2020 · Alaattin Kaya, Marco Mariotti, et al. · Nature Communications · 29
PDF
In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation
2019 · Elena M. Smekalova, Maxim V. Gerashchenko, et al. · Molecular Therapy — Nucleic Acids · 17
PDF
Tolerance to Selenoprotein Loss Differs between Human and Mouse
2019 · Didac Santesmasses, Marco Mariotti, et al. · Molecular Biology and Evolution · 57
Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs
2019 · Janinah Baclaocos, Didac Santesmasses, et al. · Journal of Molecular Biology · 26
PDF
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
2019 · Alexander Tyshkovskiy, Perinur Bozaykut, et al. · Cell Metabolism · 166
PDF
Selenium Deficiency Is Associated with Pro-longevity Mechanisms
2019 · Sun Hee Yim, Clary B. Clish, et al. · Cell Reports · 69
PDF
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
2018 · Yichong Zhang, Ji-Hoon Lee, et al. · Science Signaling · 101
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension
2018 · Andriy O. Samokhin, Thomas Stephens, et al. · Science Translational Medicine · 126
PDF
Mechanisms of cancer resistance in long-lived mammals
2018 · Andrei Seluanov, Vadim N. Gladyshev, et al. · Nature reviews. Cancer · 324
Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans
2018 · Xuming Zhou, Di Sun, et al. · Genome Biology and Evolution · 30
PDF
Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing
2017 · Bradley A. Carlson, Byeong Jae Lee, et al. · Methods in molecular biology · 29
A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging
2017 · Alexey Golubev, Andrew D. Hanson, et al. · Antioxidants and Redox Signaling · 42
Cytochrome c peroxidase facilitates the beneficial use of H 2 O 2 in prokaryotes
2017 · Alaattin Kaya, Marco Mariotti, et al. · Proceedings of the National Academy of Sciences · 16
PDF
Translation fidelity coevolves with longevity
2017 · Zhonghe Ke, Pramit Mallik, et al. · Aging Cell · 76
PDF
Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P
2017 · Kostja Renko, Janine Martitz, et al. · Scientific Reports · 23
PDF
Non-enzymatic molecular damage as a prototypic driver of aging
2017 · Alexey Golubev, Andrew D. Hanson, et al. · Journal of Biological Chemistry · 69
PDF
Year
Topic