Bovine leukemia virus infection as a model of HTLV-1 -Dok genes function-
Description: Downstream of tyrosine kinase (DOK) family molecules act suppressively on cancer development. Therefore, we also searched for the expression of the DOK gene in the blood cells of healthy cattle, which has not been well known, and the expression in bovine leukemia tumors and their tumor lines. In healthy bovine blood cells, DOK1 / 2 was expressed in T cells and DOK1 / 3 was expressed in B cells, which was similar to the report in mice. On the other hand, the expression level of the DOK3 gene in the bovine leukemia cell line KU-1, which is derived from B cells, was more than 4-fold higher than that in normal B cells. The DOK3 gene in field bovine lymphoma was also expressed about twice as high as normal B cells on average. On the other hand, the expression of the DOK1 / 2 gene was the same as that of healthy cattle.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Takeo Ohsugi
Institution: Rakuno Gakuen University
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 10
Funder award ID: 18K06036
OpenAlex ID: G1486090300