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Epithelial Protective Effects of Thyroid Hormone Signaling in Fibrosis

Description: PROJECT NARRATIVE The most common form of pulmonary fibrosis, idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by epithelial injury, fibroblast accumulation and extensive remodeling in the lung. IPF affects approximately 5 million people worldwide and, despite extensive research efforts and two FDA approved drugs, remains a significant health burden and an unmet therapeutic need. In this proposal we aim to use thyroid hormone signaling to improve mitochondrial function and enhance epithelial cell survival as an antifibrotic strategy.
Funding type: research
Funder scheme: R01
Start date: 2018-12-15
End date: 2024-11-30
Investigator: NAFTALI KAMINSKI
Institution: YALE UNIVERSITY
Field: Medicine
Funded outputs count: 67
Funder award ID: R01HL141852
OpenAlex ID: G401128902
Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows
2026 · Claudia Carducci, Naftali Kaminski, et al. · Frontiers in Medicine · 1
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Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation
2026 · Lena M. Leiber, Leonard Christian, et al. · European Respiratory Journal · 2
Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF
2026 · Yosuke Sakamachi, Emma Wiley, et al. · Science Translational Medicine · 1
Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosis
2026 · Aurelien Justet, Venerino Poletti, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
2026 · Jannik Ruwisch, Aurélie Cazes, et al. · Science Advances · 5
Stem cell migration drives lung repair in living mice
2026 · Maurizio Chioccioli, Shuyu Liu, et al. · Developmental Cell
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
2026 · Ruben De Man, Zhongyu Cai, et al. · Aging Cell · 6
Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease
2026 · Yuening Zhang, Huanhuan Wei, et al. · Nature Genetics · 18
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
2026 · Ruben De Man, John E. McDonough, et al. · Nature Communications · 12
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Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders
2025 · Felix J. Klimitz, Yizhuo Shen, et al. · Frontiers in Immunology · 25
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Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling
2025 · Sang-Hun Kim, Jessica Nouws, et al. · Science Translational Medicine · 9
Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort
2025 · Vickram Tejwani, Russell P Bowler, et al. · BMJ Open Respiratory Research · 1
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A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
2025 · Yumin Zheng, Jonas C. Schupp, et al. · Nature Biomedical Engineering · 34
Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis
2025 · Taylor S Adams, Jonas C Schupp, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 13
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
2025 · Riham Smoom, Catherine Lee May, et al. · Nucleic Acids Research · 4
eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis
2025 · Nancy G. Casanova, Jose D. Herazo-Maya, et al. · American Journal of Respiratory Cell and Molecular Biology · 14
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Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis
2024 · Amy Y. Zhao, Avraham Unterman, et al. · American Journal of Respiratory and Critical Care Medicine · 50
Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1
2024 · Philip Z. Mannes, Taylor S. Adams, et al. · Science Advances · 15
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Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis
2024 · Avraham Unterman, Amy Y. Zhao, et al. · American Journal of Respiratory and Critical Care Medicine · 97
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Stem cell migration drives lung repair in living mice
2024 · Maurizio Chioccioli, Shuyu Liu, et al. · Developmental Cell · 26
Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis
2024 · Olivia C Leavy, Anne F Goemans, et al. · medRxiv · 3
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Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner
2024 · Carole Y. Perrot, Theodoros Karampitsakos, et al. · American Journal of Physiology-Cell Physiology · 29
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Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
2024 · Joanna Obacz, Jose Antonio Valer, et al. · European Respiratory Journal · 16
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Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in Chronic Obstructive Pulmonary Disease
2023 · Tien Peng · American Journal of Respiratory and Critical Care Medicine · 3
Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis?
2023 · Xiting Yan, Naftali Kaminski · American Journal of Respiratory and Critical Care Medicine · 2
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