Contribution of brown fat thermogenesis to the anti-obesity effect of dietary protein and amino acid.
Description: To clarify a role of brown adipose tissue (BAT) in postprandial thermogenesis, energy expenditure after intake of a high-protein meal was measured in healthy human subjects. When compared with the response to a control meal, the protein-induced thermogenesis was found to be higher in subjects with high BAT activity than those with low BAT activity. These results suggest a significant role of BAT in protein-induced thermogenesis.Blood amino acid levels were compared between the high and low BAT groups.Although blood levels of all amino acids of the two groups were comparable under a thermoneutral warm condition, branched chain amino acids (BCAA) levels were decreased after 2-hr cold exposure only in the high BAT group. It is thus suggested that BCAA may be actively metabolized by BAT in humans.
Amount: ¥4,030,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2015-04-01
End date: 2017-03-31
Investigator: Mami MATSUSHITA
Institution: Tenshi College
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 1
Funder award ID: 15K16215
OpenAlex ID: G1503884612