Role of the Lin28b/let-7 axis in the maturation of hematopoietic progenitor cells
Description: PROJECT NARRATIVE During normal development, hematopoietic stem and progenitor cells undergo dramatic transitions in self- renewal, potency, and lineage bias, and understanding the mechanisms underlying such changes are critical to research in age-specific blood disorders. I previously found that the heterochronic Lin28b/let-7 signaling node functions as a key specifier of the developmental state of myeloerythroid progenitor cells, likely through regulation of the transcriptional programs that control lineage commitment. This proposal aims to better understand the mechanisms by which Lin28b/let-7 defines the developmental state of hematopoietic progenitor cells by investigating progenitor maturation at the single cell level.
Funding type: career_development
Funder scheme: K08
Start date: 2017-07-01
End date: 2023-04-30
Investigator: ROBERT GRANT ROWE
Institution: BOSTON CHILDREN'S HOSPITAL
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 14
Funder award ID: K08DK114527
OpenAlex ID: G4106355709