Making the new mathematical model of the regulation of glucose homeostasis under the condition of non-physiological urinary glucose excretion after sodium-glucose cotransporter 2 inhibition
Description: We made a new mathematical model by adding a urinary glucose excretion flux to the feedback loop between glucose and insulin, which was previously reported. In this new model, parameters were calculated for each subject using time-dependent data (for example, blood glucose level, insulin level, etc.) in 68 patients with type 2 diabetes who took SGLT2 inhibitors in the hyperinsulinemic-euglycemic clamp examination. As same as previously report, there was the strong positive correlation between insulin clearance and insulin sensitivity × secretory index. Furthermore, when the principal component analysis of the parameters was performed in both the SGLT2 inhibitor group and the control group, the parameter, that was the most strongly distinguishable between two groups, is the glucose production from the liver.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Tomoaki Nakamura
Institution: Kobe University
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Funded outputs count: 1
Funder award ID: 17K16148
OpenAlex ID: G152095759