Functional analysis of the metabotropic glutamate receptor and the acid-sensitive ion channels as a urine collection control molecule
Description: The study using metabotropic glutamate receptor subtype 1 (mGluR1) gene deficit (KO) mice and mGluR5 antagonist revealed that mGluR1 and mGluR5 are involved in excitatory afferent signal transmission from the bladder in control of lower urinary tract (LUT) function and that the mGluR phenotype has a sex difference in the LUT function. Moreover, another study showed that acid-sensing ion channels (ASICs) are associated with excitatory afferent signal transduction in acid-induced bladder hyperreflexia as well as normal bladder activity. The present studies show that mGluR1, mGluR5 and ASICs can be target molecules for development of pharmacotherapy of lower urinary tract dysfunction such as bladder overactivity and thus these results would contribute to ameliorating a quality of life of patients who suffer from such dysfunction and to improving social productivity.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Mitsuharu YOSHIYAMA
Institution: University of Yamanashi
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 14
Funder award ID: 16K11042
OpenAlex ID: G152454847