Aging, Polypharmacy and Neurotoxicity in Adults Living with HIV
Description: PROJECT NARRATIVE Polypharmacy is an increasingly common problem among aging persons with HIV (PWH), particularly since it could worsen toxicity from antiretroviral therapy and the adverse effects of comorbid diseases. This application proposes to systematically evaluate the influence of aging and concomitant drugs on ART neurotoxicity and its effects on cognition and depression and to explore the molecular and cellular mechanisms. The identification and validation of pharmacological factors affecting ART neurotoxicity, cognition, and depression would have substantial public health relevance and could support early intervention and treatment optimization.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-05-01
End date: 2026-02-28
Investigator: SCOTT L LETENDRE (lead)
Institutions: University at Buffalo, State University of New York, STATE UNIVERSITY OF NEW YORK AT BUFFALO
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Funded outputs count: 17
Funder award ID: R01AG063659
OpenAlex ID: G38353664