Pericyte-endothelial cross talk in vascular stability after kidney injury
Description: Acute Kidney Injury, Chronic Kidney Disease and End Stage Kidney Disease are major health burdens. Pericytes are cells of the kidney that have recently been descibed to play a major role in kidney disease. In health these cells nurture small blood vessels of the kidney but after injury migrate from the small vessels leading to instability and loss of these precious vessels. These studies will investigate the mechanisms by which pericytes nurture kidney blood vessels and the mechanisms by which they detach in response to injury and thereafter fail to nurture. In understanding these processes we hope to develop new therapies to treat kidney diseases.
Funding type: research
Funder scheme: R01
Start date: 2012-09-03
End date: 2017-06-30
Investigator: STUART JAMES SHANKLAND
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 49
Funder award ID: R01DK093493
OpenAlex ID: G6140499397