Hormonal Regulation of Fat Deposition
Description: The ability to regulate fat storage and metabolism are fundamental processes. However, the dual epidemics of obesity and diabetes endanger millions and are altering our health care landscape. This crisis that could be addressed by identifying genes that control formation, expansion, and remodeling of adipose tissue-for example that regulated by estrogen. We recently identified the adipose stem cell and found that it is important in the normal maintenance of adipose tissue mass and the response to diabetes treatments. Further, adipose lineage cells appear critical for the medically relevant adipose remodeling induced by estrogen or estrogen-deficiency. Our goal is to unravel the developmental, physiological and molecular mechanisms underlying these effects, which we believe will enhance our understanding of adipocyte biology and may lead to novel therapeutic targets for obesity and diabetes.
Funding type: research
Funder scheme: R01
Start date: 2010-05-01
End date: 2016-04-30
Investigator: JONATHAN M GRAFF
Institution: UT SOUTHWESTERN MEDICAL CENTER
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 27
Funder award ID: R01DK088220
OpenAlex ID: G8096020721