Elucidation of cell fate determination mechanism of skeletal muscle stem cells
Description: We examined three molecules regulating the cell fate decision of muscle satellite cells. We clarified the downstream signaling pathway of calcitonin receptor (in revision). We also demonstrated that Hey1/HeyL forms heterodimers with Hes1, an effector molecule of Notch signaling, which funcions to maintain undifferentiated state of muscle satellite cells (Development 2019). Regarding Nrf2, we showed Nrf2-mediated pathway allow muscle satellite cells to survive without basal lamina-mediated signaling (J. Cell. Physiol., 2019).
Amount: ¥17,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: So-ichiro FUKADA
Institution: Osaka University
Funded outputs count: 3
Funder award ID: 16H03262
OpenAlex ID: G1592025343