Understanding a mechanism regulating intracellular dynamics of metal ions
Description: To understand intracellular dynamics of metal ions (copper ions, in particular), I have focused upon Cu/Zn-superoxide dismutase (SOD1), which is one of the most important copper proteins, as well as the copper chaperone protein CCS that supplies copper ions to SOD1. This study has suggested a new mechanistic action of CCS on SOD1 upon the copper supply and also newly identified a protein interacting with CCS. Furthermore, the breakdown of a copper supplying step to SOD1 was evaluated as a possible pathological change occurring in a neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Misfolded SOD1 that is unable to bind copper ions has been proposed as a pathogenic species causing ALS.
Amount: ¥17,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Yoshiaki Furukawa
Institution: Keio University
Funded outputs count: 20
Funder award ID: 16H04768
OpenAlex ID: G1597422415