Mapping the cell specific DNA damage-induced molecular and bioelectrical responses in the 3D cardiac unit
Description: PROJECT NARRATIVE Increased DNA damage and DNA damage response (DDR) activation is well-documented in cardiovascular disease (CVD) and heart failure in humans, but no current treatment strategies exist to target this population. Here, applying cutting-edge optical, biological, and bioelectrical tools we will map cardiac tissue cell-cell communication and electrophysiology in response to stochastic endogenous DNA damage. Deeper understanding of the regulatory network that mediates the genotoxic stress response in the cardiac tissue will suggest preventive strategies and therapeutic interventions to reduce public health burden.
Funding type: research
Funder scheme: R01
Start date: 2021-12-15
End date: 2026-11-30
Investigator: TZAHI COHEN-KARNI
Institution: CARNEGIE-MELLON UNIVERSITY
Funded outputs count: 9
Funder award ID: R01HL161106
OpenAlex ID: G9000888696