Role of adipose tissue inflammaging and metabolic dysfunction during sepsis
Description: PROJECT NARRATIVE This application focuses on the roles of the activation of the immune cells within visceral adipose tissue during sepsis in the elderly. We investigate how inflammasome activated-macrophages and adipose B cells contribute to impaired lipolysis during sepsis. The cellular signaling mechanisms that are identified will provide new therapeutic targets to reduce morbidity to septic infection in the elderly.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2022-12-01
End date: 2027-11-30
Investigator: CHRISTINA CAMELL
Institution: UNIVERSITY OF MINNESOTA
Funded outputs count: 13
Funder award ID: R01AG079913
OpenAlex ID: G9000862924