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[Jang R01AG058560 transfer] Role of BubR1 as a juvenile protective factor in hippocampal aging

Description: PROJECT NARRATIVE Cognitive impairments are a common feature in aging and aging-related disorders, yet the underlying molecular mechanisms remain unknown. The results of this study are essential towards delineating how hippocampal dysfunction correlates with an aging-implicated component to affect cognitive function. This understanding will help guide a rational approach to designing and developing interventions targeting age- related cognitive deficits.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2018-03-15

End date: 2024-12-31

Investigator: MI-HYEON JANG

Institution: RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL

Funded outputs count: 17

Funder award ID: R01AG058560

OpenAlex ID: G6978482895

Adenosine and adenosine receptors in metabolic imbalance-related neurological issues

2024 · Mi-Hyeon Jang, Juhyun Song · Biomedicine & Pharmacotherapy · 27

The selective cyclooxygenase-2 inhibitor NS398 ameliorates cisplatin-induced impairments in mitochondrial and cognitive function

2023 · Mohammad Abdur Rashid, Jason J. Tang, et al. · Frontiers in Molecular Neuroscience · 12

Nanotechnology Approaches for Prevention and Treatment of Chemotherapy‐Induced Neurotoxicity, Neuropathy, and Cardiomyopathy in Breast and Ovarian Cancer Survivors

2023 · Sarah Nevins, Callan D. McLoughlin, et al. · Small · 30

Data from Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

2023 · Ki Hyun Yoo, Jason J. Tang, et al.

Chemobrain: An accelerated aging process linking adenosine A2A receptor signaling in cancer survivors

2023 · Alfredo Oliveros, Michael Poleschuk, et al. · International review of neurobiology · 5

Nicotinamide Mononucleotide Prevents Cisplatin-Induced Mitochondrial Defects in Cortical Neurons Derived from Human Induced Pluripotent Stem Cells

2022 · Mohammad Abdur Rashid, Alfredo Oliveros, et al. · Brain Plasticity · 15

Editorial: Adult neurogenesis as a regenerative strategy for brain repair

2022 · Daniel A. Berg, Kyung-Ok Cho, et al. · Frontiers in Molecular Neuroscience · 2

Adenosine A 2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function

2022 · Alfredo Oliveros, Ki Hyun Yoo, et al. · Proceedings of the National Academy of Sciences · 32

Early stem cell aging in the mature brain

2021 · Albina Ibrayeva, Maxwell Bay, et al. · Cell stem cell · 137

Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

2021 · Ki Hyun Yoo, Jason J. Tang, et al. · Cancer Research · 49

Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

2021 · Lee Peyton, Alfredo Oliveros, et al. · Experimental & Molecular Medicine · 31

Genetic Inhibition of sFRP3 Prevents Glial Reactivity in a Mouse Model of Accelerated Aging

2020 · Ana Mia Corujo-Ramirez, Malvika Dua, et al. · International Neurourology Journal · 7

Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

2019 · Jason Tang, Alfredo Oliveros, et al. · International Neurourology Journal · 56

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death

2019 · Ambrosia J Simmons, Raehee Park, et al. · Human Molecular Genetics · 25

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice

2019 · Chang Hoon Cho, Ki Hyun Yoo, et al. · Aging Cell · 17

BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice

2018 · Chang Hoon Cho, Zhongxi Yang, et al. · International Neurourology Journal · 9

New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders

2018 · Syed M. Q. Hussaini, Mi Hyeon Jang · International Neurourology Journal · 35