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Impact of mitochondrial genetics on muscle oxidative capacity, fitness, and mobility in older adults

Description: PROJECT NARRATIVE Older adults experience a loss of mobility that leads to disability, which is a serious health care issue in an aging US population. Mitochondrial respiration is a key property of skeletal muscle that supports walking speed, physical function and fitness in older adults. The primary goal of this project is to explore the role of mitochondrial DNA (mtDNA) in age related changes in muscle oxidative capacity and physical function.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2022-09-30

End date: 2027-05-31

Investigator: PAUL MARTIN COEN

Institution: ADVENTHEALTH ORLANDO

Funded outputs count: 2

Funder award ID: R01AG075081

OpenAlex ID: G9000894676

Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black

2025 · Paul M. Coen, Fanchao Yi, et al. · Aging Cell · 2

The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility

2023 · Steven R Cummings, Anne B Newman, et al. · The Journals of Gerontology Series A · 87

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