ApoE4, Neurovascular Injury and Cognitive Impairment
Description: White matter damage is a major factor underlying cognitive impairment in both cerebrovascular diseases and Alzheimer’s disease, but the factors mediating the damage have not been fully established. The studies will investigate the role of ApoE4 in the damage to the white matter. The findings deriving from the proposed study will advance our knowledge of the factors causing white matter injury and will suggest new putative therapeutic targets to counteract the devastating cognitive impact of white matter damage.
Funding type: research
Funder scheme: R01
Start date: 2022-04-01
End date: 2027-03-31
Investigator: COSTANTINO IADECOLA
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Funded outputs count: 14
Funder award ID: R01NS126467
OpenAlex ID: G9000866696