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mitoBone: Mitochondrial performance on osteoclast differentiation and biology during E2 deprivation – Innovative targets for osteoporosis treatment

Description: Ciências Biológicas
Amount: €80,020
Funding type: fellowship
Funder scheme: OE
Start date: 2018-12-01
End date: 2023-01-31
Investigator: Adriana Marques Carvalho
Institution: UNIVERSIDADE DE COIMBRA - INSTITUTO DE INVESTIGAÇÃO INTERDISCIPLINAR
Funded outputs count: 5
Funder award ID: SFRH/BD/140817/2018
OpenAlex ID: G1637549733
ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
2023 · Adriana Marques-Carvalho, Vilma A. Sardão, et al. · Frontiers in Endocrinology · 22
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The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism
2023 · Adriana Marques-Carvalho, Beatriz Silva, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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The role of reactive oxygen species in bone cell physiology and pathophysiology
2023 · Adriana Marques-Carvalho, Ha-Neui Kim, et al. · Bone Reports · 71
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
2022 · Ricardo Amorim, Inês C.M. Simões, et al. · Redox Biology · 47
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The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production
2021 · Inês C. M. Simões, Ricardo Amorim, et al. · International Journal of Molecular Sciences · 58
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